In this study, to determine the actual clinical utility of MRM assay for CFH SNP genotyping, we analyzed the correlation between the genotype of the major CFH SNPs rs1061170 (Y402H) and rs800292 (I62V) and the concentration ratios of plasma CFH variants measured using the MRM assay in a cohort of AMD patients and normal controls. This evidence concerns the gene CFH and age-related macular degeneration.