Previous genome-wide association studies and validation studies revealed that the variants of complement factor H (CFH) are strongly associated with the risk of AMD: risk allele of CFH single nucleotide polymorphism (SNP) rs1061170 (risk allele: C, tyrosine 402 to histidine [Y402H]) and rs800292 (risk allele: G, isoleucine 62 to valine [I62V])4–9. The gene discussed is CFH; the disease is age-related macular degeneration.