However, the major risk SNPs of AMD are CFH and ARMS2 (odds ratio: ARMS2 SNP rs10490924, 3.13; CFH SNP rs1061170, 2.74; CFH SNP rs800292, 2.43), while the other known SNPs related to AMD have insufficient clinical significance (e.g. odds ratio: 2.82 for CFB rs4151667; 2.31 for CFB rs438999; 1.58 for SYN3/TIMP3 rs9621532; 1.52 for C3 rs2230199)18. This evidence concerns the gene TIMP3 and age-related macular degeneration.