WRN and cancer: In this regard, it would be interesting to investigate whether MSI cancer cells with (TA)n repeat expansions have the potential to evolve resistance to WRN inhibition, by altering the length and/or sequences of the (TA)n repeat expansions, by inactivating MUS81-EME1 and/or SLX4 which may alleviate the DSB formation and chromosomal shattering, or by up-regulating genome stability processes, perhaps involving promiscuous DNA helicases that might compensate for WRN inhibition in this context.