This study aimed to investigate the potency of BH3 mimetics in BP-CML through cell line and patient sample testing, and our results suggest a functional dependence of BP-CML cells on MCL-1 and BCL-xL, with significant degrees of apoptosis induced, particularly after dual-inhibition. This evidence concerns the gene BCL2L1 and chronic myelogenous leukemia, BCR-ABL1 positive.