CASP2 and early-onset autosomal dominant Alzheimer disease: Casp2 is critical for the effects of Aβ on dendritic spines in cultured neurons and has a critical role in mediating the synaptic changes and memory alteration induced by Aβ in human amyloid precursor protein transgenic mice, suggesting that Casp2 is a potential target for Alzheimer’s disease therapy [17].