Our aim was to develop a mouse model for CEL-HYB1 that enables studies of pancreatic disease mechanisms.<h4>Methods</h4>We established a knock-in mouse strain where the variable number of tandem repeat (VNTR) region of the endogenous mouse Cel gene was substituted with the mutated VNTR of the human CEL-HYB1 allele. The gene discussed is CEL; the disease is pancreas disorder.