AKT1 is involved in a variety of tumor-related biological processes.21 Several studies have confirmed that over-activation of AKT1 is an important factor in cisplatin resistance.22,23 Here, we observed that the inhibitory activity of sevoflurane on cisplatin resistance in neuroblastoma was markedly reversed by miR-490-5p inhibitor or AKT1 overexpression plasmid, indicating that sevoflurane inhibits cisplatin resistance by regulating the linc00473/miR-490-5p/AKT1 axis. Here, AKT1 is linked to neuroblastoma.