AKT1 and neoplasm: Sevoflurane, a commonly used anesthetic, can reportedly regulate tumor development.5 Preliminary molecular mechanism studies have demonstrated that sevoflurane regulates classic tumor signal path, such as the Wingless and int-1 (WNT)/β-catenin pathway and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT signaling.5 However, whether sevoflurane can regulate cisplatin resistance and the related molecular mechanisms remain unclear.