CD4+T lymphocytes raised circulatory levels of simultaneously produced pro-inflammatory cytokines IL-17+-IL4+ and IFN-γ+-IL4+ contributing to ON inflammation at target organ site. The polyclonal stimulation with phorbol myristate acetate/ inomycin in vitro in SCD, SCD-ON showed significantly raised IL4+TCD4+ cells. The gene discussed is IL4; the disease is Schnyder corneal dystrophy.