This indicate increased T helper cells production in SCD patients bone marrow and increased CD4+T subset intensify pro-inflammatory cytokines production contributing to pathological immune responses in femoral head leading to ON in SCD patients.23 Another factor is potential reduction in mineral to matrix ratios in necrotic cells,24 indicating the ratios of carbonate at 1070 cm-1, phosphate at 958 cm-1, and collagen amide I at 1070 cm-1,= respectively, through Raman spectroscopy decreasing bone mineralization and structural strength resulting in fragility fractures. The gene discussed is CD4; the disease is Schnyder corneal dystrophy.