Interestingly and importantly, previous study reported that prohibitin 2 (PHB2), an essential IMM protein that plays important roles in lifespan, neurodegenerative diseases, and cancer, directly interacts with MAP1LC3B/LC3B (hereinafter referred to as LC3) and functions as an IMM mitophagy receptor for efficient clearance of IMM and mitochondrial matrix after ubiquitination-driven OMM rupture (15). This evidence concerns the gene MAP1LC3B and neurodegenerative disease.