SIRT1 and Parkinson disease: Previously, resveratrol (a known natural SIRT1 activator) has been shown to attenuate Parkinsonian mimetics induced by compounds such as 6-hydroxydopamine (6-OHDA), rotenone, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or its active metabolite 1-methyl-4-phenylpyridinium (MPP+) in the mammalian cells [4,45,50], fruit fly [49], and animal [1,34] models of PD.