Furthermore, molecular markers of neurodegeneration, including those shown to be associated with AD such as apolipoproteins ApoE, ApoD, and ApoC (34–36), as well as key enzyme markers such as Tgm1 (37, 38), and regulators of proteolysis such as serpinA3N and serpinA3K (39, 40), were similarly increased in prion disease and reduced by VU846 (Fig. 3C). This evidence concerns the gene APOE and prion disease.