Our results showed that the microglia were activated in STZ induced diabetes mice in hippocampus DG (Figure 7A, 7B) and CA1 (Supplementary Figures 1, 3) region, but not cortex (Supplementary Figures 2, 4), zafirlukast and bromocriptine treatment could suppress the activation of microglia in DG and CA1 regions indicated by the expression of microglia activation marker IBA1. This evidence concerns the gene AIF1 and diabetes mellitus.