ZAF, BRO and the combination of ZAF and BRO respectively reduced the expression level of NLRP3 pathway related protein NLRP3, caspase1 and IL-1β (Figure 5L), also suppressed the expression of Golph3 pathway related proteins Golph3, GM130 and vimentin of the hippocampus of diabetes mice, respectively (Figure 5M). This evidence concerns the gene IL1B and diabetes mellitus.