Our study elucidated that HG induced Golgi stress was mediated by NLRP3/Vps35/Golph3/Vimentin pathway, inhibition of NLRP3 and Golph3 by selected molecular inhibitors zafirlukast and bromocriptine could suppress neuro-inflammation and Golgi stress thus ameliorate diabetes cognitive decline. The gene discussed is GOLPH3; the disease is diabetes mellitus.