GOLPH3 and diabetes mellitus: ZAF, BRO and the combination of ZAF and BRO respectively reduced the expression level of NLRP3 pathway related protein NLRP3, caspase1 and IL-1β (Figure 5L), also suppressed the expression of Golph3 pathway related proteins Golph3, GM130 and vimentin of the hippocampus of diabetes mice, respectively (Figure 5M).