Chemokines play a crucial role in the recruitment and function of neutrophils, hence the relevance of CXCL6 in neutrophil trafficking and activation-mediated disease such as UC, interacting with receptors CXCR1 and CXCR2.40 Laminin family members, such as LAMA4, interact with members of the integrin family, promoting cell adhesion and trafficking field.47 EMILIN1-β1 and integrin interactions in the extracellular vascular matrix are essential in mediating colitis in animal models.42 Both constitutive androstane receptor and pregnane X receptor ameliorate experimental colitis through GADD45B. Here, CXCR1 is linked to colitis.