This is in contrast to the RNA sequencing studies, showing relatively suppressed expression of NRF2 in COVID-19 and with stimulation of NRF2 expression proposed as a therapeutic strategy (30, 58) Evidently, normalization with GAPDH erroneously creates the impression of NRF2 overexpression, especially in mild infections and CAM. The gene discussed is NFE2L2; the disease is infection.