In addition, the low virulence of C. cassiicola associated with its marked growth restriction at temperatures greater than 30°C (39) and its preferential habitat on crop plants and debris (51) further limits the available opportunities for this fungus to cause human infection, and thus may additionally explain the rarity of this infection despite the relatively high frequency of deleterious CLEC7A variants in the general population. Here, CLEC7A is linked to infection.