For example, the deleterious mutation p.Y238* in CLEC7A, which encodes Dectin-1, has been previously associated with familial vaginal yeast infections and onychomycosis, which was linked to impaired Dectin-1–dependent production of proinflammatory cytokines, including IL-17, in response to the Dectin-1 ligand, β-glucan, and Candida yeast cells (19). The gene discussed is CLEC7A; the disease is tinea unguium.