To assess the role of BCL6 in tumorigenesis and tumor growth in KRAS-driven lung cancer, we generated an engineered mouse model harboring the following alleles: (a) WT alleles of Bcl6 with LSL-KrasG12D/+; (b) heterozygous floxed alleles for Bcl6 with LSL-KrasG12D/+; and (c) homozygous floxed alleles for Bcl6 with LSL-KrasG12D/+. The gene discussed is KRAS; the disease is lung cancer.