Enhanced tumor lysis and NK degranulation were only observed when KIR2DL5 was blocked, either alone or with TIGIT blockade (Figure 7C and Supplemental Figure 8B), suggesting that KIR2DL5 has a dominant role over TIGIT in inhibiting KIR2DL5+TIGIT+ NK cell cytotoxicity. The gene discussed is TIGIT; the disease is neoplasm.