Upon incubation with anti-KIR2DL5 blocking mAb F8B30, KIR2DL5+ NK cells manifested more potent cytotoxicity, degranulation (CD107a), and functional cytokine (IFN-γ and TNF-α) production after coculturing with PVR+ A427 (Figure 7A) or Jurkat tumor cells (Figure 7B). Here, LAMP1 is linked to neoplasm.