Baseline CRP levelsare associated with more severe depression (Köhler-Forsberg et al., 2017) and treatmentresistance (Zhang et al.,2019) especially to serotonergic medications, such as SSRIs (i.e.escitalopram, sertraline, fluoxetine, and paroxetine) and SNRIs (i.e. venlafaxineand duloxetine). The gene discussed is CRP; the disease is major depressive disorder.