Considering most N‐glycosylation sites of S protein remain among typical SARS‐CoV‐2 variants[7, 8, 9] and the content of high mannose in glycan shields changes slightly,[20, 21, 47, 48] we speculated that high‐mannose binding nanoMIP should hold potential to protect host cells from variants infection. The gene discussed is PROS1; the disease is infection.