Furthermore, these key regulatory molecules in colon cancer metastasis and EMT progression, Snail, Vimentin and N‐Cadherin were significantly down‐regulated in the (BGN, THBS2) knockdown colon cancer cells (Figure 6E–F), which are prominent inducer of EMT, strongly repress E‐cadherin expression and promote metastasis.22, 23, 24. This evidence concerns the gene VIM and malignant colon neoplasm.