PDGFRB and colorectal cancer: For instance, MAP3K6 controls angiogenesis and tumorigenesis under normoxic and hypoxic conditions through VEG-F expression [41], increased levels of PDGFRB have been linked to decreased overall survival in gastric cancer patients, GATA2 defects can cause myelodysplasia and leukemia, and FGF6 defects are associated with the development of prostate and colorectal cancers [42–46].