These results were validated in the independent TCGA breast cancer cohort, with 113 pairs of tumor and adjacent normal breast transcriptome data (Pearson’s r = 0.45, p < 0.0001; Pearson’s r = 0.34, p = 0.0002 for GSAct and CD8A, respectively; Fig. 3B). This evidence concerns the gene CD8A and breast carcinoma.