Previously, Cozzone et al. had correlated decreased Akt2 and -3 serine phosphorylation in skeletal muscles of T2D patients, and attributed it to increased PHLPP1 mRNA levels (with no effect on PHLPP2 mRNA and corresponding no effect on Akt1 serine phosphorylation). Here, PHLPP2 is linked to type 2 diabetes mellitus.