Nitsche et al. reported that PHLPP1 regulates phosphorylation of Akt2, and PHLPP2 regulates phosphorylation of Akt1 in vitro in PaCa cells and in vivo in the orthotopic mouse PaCa model [4]. This evidence concerns the gene PHLPP2 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.