At the same time, among the genes downregulated by TD, several molecules of the KEGG pathways of Glycerophospholipid metabolism (map00564), TNF (tumor necrosis factor) signaling pathway (map04668), Cell cycle (map04110), and FoxO (Forkhead box class O) signaling pathway (map04068) and have GO annotations related to inflammatory response (GO:0006954), immune response (GO:0006955), chemokine-mediated signaling pathway (GO:0070098), cellular response to TNF (GO:0071356), and cellular response to IL-1 (GO:0071347). Here, TNF is linked to thanatophoric dysplasia.