NSD1 and thanatophoric dysplasia: Importantly, the Nsd1 gene, upregulated in TD, is annotated with GO terms related to the inhibition of neurogenesis by regulating the methylation of the lysine 36 at the histone H3 (positive regulation of transcription, DNA-templated [GO:0045893]; regulation of histone H3-K36 methylation [GO:0000414]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903025]).