Multivariate logistic analysis identified the following independent predictors: type I respiratory failure (RF), New York Heart Association (NYHA) functional class, N-terminal pro-brain natriuretic peptide (NT-proBNP) ≥ 1400 ng/L, arrhythmia, and eclampsia with pre-existing hypertension (HTN) (Additional file 1: Fig. S1A). The gene discussed is NPPB; the disease is hypertensive disorder.