We identified 10 metabolic genes associated with prognosis and were further revealed by LASSO-based Cox proportional hazard model analysis to construct the RS survival prediction model, including CD38, ZNF212, POR, CC2D1A, GRAMD4, FH, SLC24A3, GATA2, FOXD1, and MMP10. The KM curves showed that the patients with LC in the low-risk group had remarkably better survival than the low-risk group for TCGA dataset (P = 3.853e−12). This evidence concerns the gene FOXD1 and laryngotracheoesophageal cleft.