As expected, CPSF2 or CSTF3 also negatively regulated the expression of ELOA and activated AKT signaling (pAKT at Ser473 but not at Thr308) through DLGAP1-AS2 in CRC cells (Fig. 9 C and Fig.S12A-C). The gene discussed is AKT1; the disease is colorectal carcinoma.