Tsantes et al. reported that the association of the PAI-1 4G/5G polymorphism with VTE was evident in patients with genetic risk factors (such as family history of hereditary diseases), whereas this association was no longer elucidated in patients (such as antiphospholipid antibody syndrome, Bechet disease) which had no genetic risk factors [39]. This evidence concerns the gene SERPINE1 and antiphospholipid syndrome.