NPM1 and acute myeloid leukemia: The rate and durability of response to VEN based combinations in single arm studies for patients with NPM1 mutated AML compares favourably with outcomes of patients treated with IC, for example adults with the favourable risk genotype NPM1mutFLT3 ITDneg treated with IC in the intensive therapy arm of UK NCRI AML16 (median age 67 years, range 60–84 years) demonstrated overall survival rates at 2 and 3 years of 50% and 35% [26].