Recently, an increasing number of publications have suggested that LHPP serves as a tumor suppressor in different tumor types, such as hepatocellular carcinoma (HCC) [5, 27], intrahepatic cholangiocarcinoma (ICC) [11], glioblastoma [28], melanoma [29], cervical [14], bladder [10], thyroid [30], pancreatic [12], renal [13] and colorectal cancers [15, 16]. Here, LHPP is linked to intrahepatic cholangiocarcinoma.