LHPP and cancer: For instance, according to the XCELL algorithm, LHPP performance in HNSC had a positive correlation with cancer-associated fibroblasts (Cor = 0.217, P value = 1.77e−06), and LHPP expression levels in LGG were negatively associated with cancer-associated fibroblasts according to the MCPCOUNTE algorithm (Cor = − 0.33, P value = 1.28e−13).