Here, prolonged stimulation with IL-11 or its soluble receptor IL-11Rα induced transcript and protein alterations in HPAEC showing an increase of contractile and cytoskeleton proteins αSMA and vimentin, elevation of growth factors and vasoconstrictor protein ET-1, and decrease of endothelial cell markers compatible with the EnMT and endothelial dysfunction processes. Here, IL11RA is linked to endothelial dysfunction.