The conditioned media of A549 or H1975 cells transfected with si-ALKBH5 or NC was collected to treat HUVECs, and we found that tube formation was inhibited when ALKBH5 was silenced in the two lung cancer cell lines (Fig. 4C, D and Additional file 1: Fig. S3). The gene discussed is ALKBH5; the disease is lung cancer.