Subgroup analysis of KEYNOTE-189 study [37] showed that pembrolizumab combined with pemetrexed-platinum has improved ORR (40.7% vs 26.7%), PFS (9 months vs. 5 months; HR = 0.47), OS (21 months vs. 14 months; HR = 0.79) compared with pemetrexed-platinum chemotherapy in KRAS mutant non-squamous NSCLC; in patients with KRAS G12C mutant non squamous NSCLC, ORR (50.0% vs. 18.2%), PFS (11 months vs. 5 months; HR = 0.48) were improved, but not OS (18 months vs. 25 months; HR = 1.14). This evidence concerns the gene KRAS and non-small cell lung carcinoma.