Xinyue Zhou and Rui Lu discovered that SCUBE1 involving in the initiation and maintenance of MLL-rearranged (MLL-r) acute myeloid leukemia is a novel transcriptional target of HOXA9 and MEIS1 [66], understanding the role of SCUBE1 is contributed to clarify the mechanism of HOXA9/MEIS1in human diseases. The gene discussed is SCUBE1; the disease is acute myeloid leukemia.