Besides, Karatas et al. design and synthetize a series of peptidomimetics based on WDR5/ MLL1 interaction, they found that MM-589 inhibits the proliferation of leukemia cells with an IC50 value of 0.9 nM, and the inhibition ratio is better than the previously reported compound MM-401 [130]. The gene discussed is KMT2A; the disease is leukemia.