For example, it classified 89% of intronic non-canonical splice-altering variants in ACVRL1, a gene that has well-characterized intronic splice-altering variants that cause Hereditary Hemorrhagic Telangiectasia (HHT2 [MIM: 600376]), with constraint scores at or above 0.88 (Fig. 4A–C). This evidence concerns the gene ACVRL1 and hereditary hemorrhagic telangiectasia.