In the retrospective analysis conducted comparing the cardiometabolic and inflammatory biomarkers during puberty by prepubertal obesity degree and the prepubertal presence or not of MetS, we observed that children with obesity but no MetS at prepuberty had significantly lower values of zBMI, TNF, resistin, and adiponectin between the pubertal stages. This evidence concerns the gene RETN and obesity due to melanocortin 4 receptor deficiency.