It is apparent that T cells represented by conventional αβ CD8 + effector cells and also by γδ T cells in CML patients at diagnosis display alterations in a) numbers, where significant expansions in both major γδ T cell subsets were shown in our study and in particular in b) phenotype of exhaustion/terminal differentiation. Here, CD8A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.