To confirm the effect of EFNB2 on CRC LM, we injected sh-NC or sh-EFNB2 SW620 cells into the spleen of nude mice to establish the LM model and found that EFNB2 knockdown reduced the tumor burden of CRC LM (Figs. 1L, S1C). The gene discussed is EFNB2; the disease is neoplasm.