EFNB2 and colorectal carcinoma: Disruption of reverse signaling by transfection with ΔC EFNB2 and ΔC + H EFNB2 showed a comparable metastatic tumor burden with EFNB2 FL, indicating that reverse signaling of EFNB2 was not involve in promoting post-metastatic growth of CRC LM (Figs. 2D and S2A).