HMGCS1 and colorectal carcinoma: Analysis of the CRC LM (GSE6988, GSE35834 and GSE49355), compared with CRC primary tumor, indicated that the expression of genes related to cholesterol synthesis (HMGCS1, HMGCR, MSMO1 and DHCR24) was inhibited, and that of cholesterol uptake related genes (LDLR, VLDLR and SCARB1) was upregulated in CRC LM (Fig. S4B–H).