After SLC1A5 was knockdown in HCT116 and HT29, the FITC-P-LPK showed a reduction of the fluorescence (Supplementary Fig. 10 and Fig. 6a, b), further more validated the role of SLC1A5 in the binding of P-LPK to CRC cells. Here, SLC1A5 is linked to colorectal carcinoma.