Therefore, the present work was conducted to investigate the association between NLRP3 and the progression of HCV-related liver disease by studying serum levels and hepatic expression of NLRP3 in patients with chronic HCV infection and their relation to the severity of liver injury and also, to explore whether serum NLRP3 could be a potential biomarker for HCV-related liver pathology. The gene discussed is NLRP3; the disease is liver disorder.