In this study, we additionally report the regulation of proinflammatory (IL1-α, IL1-β, IL6, IL8, IL18, and TNF-α) and regulatory (IL10, IL22, IL23, and IL33) cytokines associated with single-PDCoV and -PEDV infection, as well as PDCoV/PEDV co-infection. The gene discussed is CXCL8; the disease is coinfection.