However, additional studies have demonstrated that the regulatory effect of PEDV in the intestinal mucosa occurs much earlier, with the significant positive mRNA modulation of IL6 and other proinflammatory cytokines, including IL1-α, IL1-β, IL8, and IL18, which is detectable at 6 h post-infection (hpi)63. The gene discussed is CXCL8; the disease is infection.