The assessment of the CD8 T-cell memory pool after increasing the tumour burden showed an increase in the number of central memory and effector memory T cells upon ACK1 loss induced either by knockdown or pharmacological inhibition (Supplementary Fig. 12a, b), indicating that ACK1 inhibition leads to higher T-cell responses, inducing for long-term memory for tumour antigens. This evidence concerns the gene TNK2 and neoplasm.