Moreover, the promoter region of KMT5B (cg1766288, cg2010049) is much more methylated in sarcomas compared to carcinomas such as THCA, PRAD, LUAD and BRCA, probably accounting for transcriptional repression of KMT5B (Supplementary Fig. 8g–j). The gene discussed is KMT5B; the disease is carcinoma.