For example, rs1260326 (GCKR) which was associated with higher CRP and LDL levels, but lower BMI in MTAG, was also associated with 28 diseases in PheWAS including direct associations with disorders of lipid metabolism (P = 2 × 10−22), gout (P = 3.9 × 10−18), and angina pectoris (P = 3.9 × 10−4) and inverse associations with type 2 diabetes (P = 3.6 × 10−13), cholelithiasis (P = 9.5 × 10−12), alcoholism (P = 1.8 × 10−4), and fasciitis (P = 6.7 × 10−4). This evidence concerns the gene CRP and cholelithiasis.