Another variant, rs1421085 (FTO) was associated with 27 diseases including direct associations with obesity (P = 5.6 × 10−39), type 2 diabetes (P = 8.2 × 10−27), and hypertension (P = 6.4 × 10−9) and inverse with breast cancer (P = 1 × 10−11), and fasciitis (P = 3.1 × 10−4). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.