ACTN2 and cardiomyopathy: In a sensitivity analysis considering HF, LVEF, LVEDV and LVESV indexed for body surface area, or in a combined analysis including both indexed and unindexed ventricular volumes, we similarly identified significant enrichment of loci located near known cardiomyopathy genes (BSA-indexed: ACTN2, ALPK3, BAG3, FLNC, TTN, hypergeometric p = 6.82 × 10−4; combined: ACTN2, ALPK3, BAG3, FLNC, PLN, TTN, hypergeometric p = 1.28 × 10−6).