After comparing these potential PD-L1-interacting molecules with genes upregulated and negatively associated with tumor CD8+ T cell infiltration33 in the TCGA BRCA dataset (Supplementary Table 2), TMUB1 was found to be an interesting candidate for further investigation (Fig. 1d and Supplementary Fig. 1f, g). The gene discussed is TMUB1; the disease is neoplasm.