Acute and chronic hyperglycaemia regulated PDHe1α phosphorylation in LG-cells and HG-cells in a similar manner to that observed in control and diabetic islets (Fig. 9c, d); and chronic GAPDH inhibition in LG-cells recapitulated the effect of chronic hyperglycaemia on PDHe1α phosphorylation (Fig. 9c, d). Here, GAPDH is linked to Hyperglycemia.