This dose is equivalent to an adult dose of 1 000 mg per d at 60 kg, according to the food and drug administration (FDA), which is the starting dose of metformin in humans (500 mg per d twice daily).25 Intraperitoneal administration of metformin partially mitigated osteopenia and restored bone formation in the OC-Cre; Pck2f/f mice. The gene discussed is BGLAP; the disease is Osteopenia.