In addition, consistent with higher percentage of effector-memory CD8+ T cells in non-cachexia patients, genes relevant to the dysfunctional phenotype and the state of inactivation such as MT1X, MT1E, IL7R, and ZFP36L2 were highly expressed in CD8+ T cells in non-cachexia patients (Fig. 6c). Here, CD8A is linked to Cachexia.