TNFAIP6 and Cachexia: We hypothesized that the occurrence of cachexia-specific inflammatory progenitor cells in SAT was presumably attributed to tumor-derived factors and used marker genes identified by our scRNA-seq data including CCL2, CXCL2, TNFAIP6, and TNFRSF12A to indicate the transformation of adipogenic progenitor cells into inflammatory progenitor cells by tumor cells (Supplementary Table S2).