B cells from patients with cachexia showed lower expression of MHC-II molecules (HLA-DRB5, HLA-DQA2) and higher expression of the immunoglobulins (IGHG2, IGHG3, IGKC), and genes involved in BCR signaling (Supplementary Fig. S6c, d and Table S3c). Here, IGKC is linked to Cachexia.