We hypothesized that the occurrence of cachexia-specific inflammatory progenitor cells in SAT was presumably attributed to tumor-derived factors and used marker genes identified by our scRNA-seq data including CCL2, CXCL2, TNFAIP6, and TNFRSF12A to indicate the transformation of adipogenic progenitor cells into inflammatory progenitor cells by tumor cells (Supplementary Table S2). The gene discussed is CXCL2; the disease is Cachexia.