We previously demonstrated, among other groups,30 that patients with COVID-19 with delirium exhibit a higher level of interleukin-8 (IL-8) and chemokine ligand 2 (CCL2) in the CSF correlating with peripheral inflammation.17 This was associated with signs of blood-brain barrier dysfunction17 and strong glial (astrocytes and microglia) activation. Here, CXCL8 is linked to delirium.