CHD8 and Hirschsprung disease: Contrary to Hirschsprung’s disease (HSCR; MIM#142623), a congenital condition associated with a failure of vagal NCCs to colonize the intestine (Okamoto & Ueda, 1967; Edery et al, 1994), we found that the reduced expression of chd8 does not prevent the completion of the rostro-caudal colonization of the GI tract by vagal NCCs.