Mutations in CHRNA1 and CHRNA6 have been implicated in fast-channel congenital myasthenic syndrome (MIM#608930) characterized by early-onset progressive muscle weakness and chronic pain (Wieskopf et al, 2015; Natera-de Benito et al, 2017). The gene discussed is CHRNA6; the disease is Congenital myasthenic syndromes.